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Daily Dose of Gold May Reverse Parkinson's and Multiple Sclerosis Symptoms - Newsweek

The treatment, tested by researchers at the University of Texas Southwestern Medical Center, comes from an unlikely source: suspended nanocrystals of gold. Multiple sclerosis (MS) and Parkinson's disease are neurodegenerative diseases that affect the brain and spinal cord. But while MS occurs when the immune system attacks the insulation around our nerve cells, Parkinson's disease is caused by a loss of dopamine-producing cells in a part of the brain called the substantia nigra, which helps control movement. Gold nanocrystals suspended in a water buffer represent a novel therapeutic agent developed by Clene Nanomedicine for neurodegenerative conditions.Gold nanocrystals suspended in a water buffer represent a novel therapeutic agent developed by Clene Nanomedicine for neurodegenerative conditions. Random 42/Clene Nanomedicine · As we age, our brain's ability to produce energy does steadily decline. However, this decline is accelerated by diseases like MS and Parkinson's.To explore this possibility, neurology professor Peter Sguigna and his team partnered up with the company Clene Nanomedicine, which has been developing these gold nanocrystals into an orally administered therapeutic agent for neurodegenerative conditions. In their study, published in the Journal of Nanobiotechnology and funded by Clene Nanomedicine, the team recruited 11 patients with relapsing MS and 13 with Parkinson's for two phase two clinical trials."We are cautiously optimistic that we will be able to prevent or even reverse some neurological disabilities with this strategy," researchers said.

I Tried McDonald’s New Special Edition Gold Sauce

McDonald’s has dropped their new Special Edition Gold Sauce and I got to try it. The Gold Sauce, as described by McDonald’s, is inspired by the tangy, sweet-and-smoky flavor profile of North Carolina barbecue. Some of its ingredients include mustard, honey, and smoke. I love the combination of sweet and savory flavors, and I enjoyed how this sauce was a bit more mustard forward than other sauces in similar categories.This was my first time trying a McDonald’s snack wrap in general, and it’s safe to say that it did not disappoint. The wrap consists of crispy chicken, lettuce, cheese, and the Special Edition Gold Sauce, and each element of the wrap comes together to create a delicious, cohesive flavor.The Bacon Special Edition Gold McCrispy comes in two versions: normal and deluxe. The normal hits all the notes of a classic chicken sandwich, and the pickle flavor cuts through the richness of the chicken and the sauce. The deluxe version is for those who enjoy an amped-up bite.Whenever my parents and I drive to Austin to drop me off at college, our favorite road trip stops are Buc-ee’s and McDonald’s. If you’re ever been on a road trip in Texas, you know that Buc-ee’s is the best for cheap gas and large restrooms. As for McDonald’s, my parents and I just like their chicken nuggets. I’m a simple girl – my go-to sauce at McDonald’s has always been ketchup. However, this might be changing now that McDonald’s has dropped their new Special Edition Gold Sauce.

Daily gold nanocrystal drink promising as MS and Parkinson’s treatment

Phase 2 clinical trials using orally administered gold nanocrystals to treat multiple sclerosis and Parkinson’s disease have produced promising results, restoring metabolites linked to crucial energy activity in the brain that are depleted in these neurodegenerative conditions. Now, researchers from the University of Texas Southwestern (UT Southwestern) Medical Center have conducted two phase 2 clinical trials on patients with MS and PD to see whether treating these neurodegenerative diseases with orally administered gold nanocrystals could restore the NAD+/NADH ratio.The REPAIR-MS trial recruited 11 participants aged 18 to 55 with a diagnosis of stable relapsing MS within 15 years of screening, a form of the condition that’s marked by worsening symptoms (relapse) followed by a period of remission. Participants were receiving treatment with the immunotherapy drug natalizumab. The surface of the gold nanocrystals rapidly catalyzes NADH to NAD+Beginning with the baseline visit, participants had ECG, blood tests, physical exams, and scoring of either motor and non-motor Parkinson’s symptoms or the degree of disability caused by MS. Phosphorous magnetic resonance spectroscopy (P-MRS) was used to noninvasively assess energy metabolites of the whole brain. After 12 weeks of treatment with CNM-Au8, the mean change in NAD+/NADH ratio from baseline across both cohorts demonstrated a statistically significant increase by an average of 10.4%, demonstrating that the gold nanocrystals were targeting the brain as intended.“We are cautiously optimistic that we will be able to prevent or even reverse some neurological disabilities with this strategy,” said Peter Sguigna, one of the study’s co-authors and lead on the MS trial. CNM-Au8 is a concentrated suspension of gold nanocrystals whose surfaces catalyze the rapid oxidation of NADH to NAD+, shown to increase the availability of both NAD+ and ATP in in vitro studies.

Novel gold therapeutic linked to improved outcomes in MS at 96 weeks

DENVER — Daily treatment with a suspension of gold crystals was linked to improved outcomes at 96 weeks for those with stable relapsing multiple sclerosis, according to a speaker at the American Academy of Neurology annual meeting.“This is an oral suspension of gold nanocrystals, approximately ... Treatment with a novel oral gold suspension was linked to improved outcomes for those with MS at 96 weeks in the long-term extension of the VISIONARY-MS clinical trial.DENVER — Daily treatment with a suspension of gold crystals was linked to improved outcomes at 96 weeks for those with stable relapsing multiple sclerosis, according to a speaker at the American Academy of Neurology annual meeting.“This is an oral suspension of gold nanocrystals, approximately 1.2 quadrillion of them,” Michael Barnett, MBBS, PhD, clinical neurologist at theResults from the double-blind portion of the VISIONARY-MS study found that the oral, investigational CNM-Au8 treatment improved low contrast letter acuity (LCLA) and global neurological function assessed by the modified MS Functional Composite (MSFC) compared with placebo in patients with stable relapsing MS on approved disease-modifying immunomodulatory therapies (DMTs).In addition to safety, functional endpoints were assessed at clinical visits every 12 weeks: LCLA for each eye by 2.5% Sloan letter chart, modified MSFC score including the Timed 25-Foot Walk (T25FWT), Symbol Digit Modality Test (SDMT), 9-Hole Peg Test (9HPT, dominant and non-dominant hands), and LCLA (both eyes).

Aka New money (@msgold_) • Instagram photos and videos

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Novel Drug Made of Gold Nanocrystals Appears Safe in Multiple Sclerosis | MedPage Today

DENVER -- An oral suspension of clean-surfaced gold nanocrystals known as CNM-Au8 was safe and well-tolerated in patients with stable relapsing-remitting multiple sclerosis (MS) and chronic optic neuropathy, the long-term open-label extension of a phase II trial showed. "The field of MS therapeutics has had great success modulating the immune system and preventing MS damage," Bermel pointed out. "Over the last two decades, we've gotten really good at that, and we have highly effective therapies now to prevent new immune damage." But the field has not been able to improve function that's already lost, he observed. The CNM-Au8 studies may be trying to do that -- "turn back the clock a little bit," he noted. Preclinical studies suggest that gold nanocrystals target mitochondrial function and the nicotinamide adenine dinucleotide (NAD) pathway, possibly preventing neuronal axons from degrading and allowing for remyelination."Unlike old gold therapies that we used to use for things like rheumatoid arthritis, which had lots of side effects ... [CNM-Au8] is pure gold nanocrystals. It's got a very clean safety profile with no real side effects," Barnett told MedPage Today. In VISIONARY-MS and its extension study, other outcomes included paraclinical biomarker data.Small study suggested benefits for MS patients with chronic optic neuropathyThe extension study assessed the long-term safety and efficacy of 30 mg daily CNM-Au8 on participants over 96 weeks after the 48-week double-blind phase II VISIONARY-MS trial. The phase II data, presented at last year's AAN meeting, showed that CNM-Au8 improved low-contrast letter acuity (LCLA) by 3.13 letters relative to a placebo group (P=0.056).

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Gold nanoparticles found to reverse brain deficits in multiple sclerosis and Parkinson's

Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson's disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and ... Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson's disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.REPAIR-MS will continue to enroll participants to see whether similar findings can be reproduced in progressive MS. More information: Jimin Ren et al, Evidence of brain target engagement in Parkinson's disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials, Journal of Nanobiotechnology (2023). DOI: 10.1186/s12951-023-02236-z ... Citation: Gold nanoparticles found to reverse brain deficits in multiple sclerosis and Parkinson's (2024, February 13) retrieved 8 September 2025 from https://phys.org/news/2024-02-gold-nanoparticles-reverse-brain-deficits.htmlHowever, studies have shown that in neurodegenerative conditions such as MS, PD, and amyotrophic lateral sclerosis (ALS)—also known as Lou Gehrig's disease—this decline in the NAD+/NADH ratio is much faster and more severe.To determine whether CNM-Au8 was reaching its intended target in human patients, the UTSW researchers recruited 11 participants with relapsing MS and 13 with Parkinson's for two phase two clinical trials, REPAIR-MS and REPAIR-PD.

Drinking Tiny Gold Crystals May Help With MS Vision Problems

People with multiple sclerosis who drank a medicine containing gold nanocrystals daily for nearly 3 years got better vision, according to study results presented at a neurology conference this month. April 30, 2024 – People with multiple sclerosis who drank a medicine containing gold nanocrystals daily for nearly 3 years got better vision. Vision problems are a nearly universal symptom of multiple sclerosis (MS), which is a potentially disabling disease that affects the brain and spinal cord.Nearly 1 million people in the U.S have MS. One estimate suggests vision problems are often the first sign of the disease. Damage to nerve fibers can cause a wide range of symptoms, including sometimes losing the ability to walk.The findings have not yet been published in a peer-reviewed journal and come from treatment time added on to a phase 2 clinical trial of the experimental treatment called CNM-Au8. The initial trial included people with relapsing MS ages 18 to 55 years old who had MS for 15 years or less.There is no cure for MS.

‘Liquid gold’ could bring new hope to multiple sclerosis patients, study suggests | Fox News

An experimental medication called CNM-Au8 — a drinkable liquid with gold nanocrystals — has shown promising results in clinical trials for improving MS symptoms. Doctors and researchers weighed in. The gold liquid suspension was found to have a "profound clinical benefit," with the patients experiencing · physical improvements not achieved in prior trials. Multiple sclerosis is an autoimmune disease of the central nervous system, brain, spinal cord and optic nerve. In people with MS, white cells called lymphocytes infiltrate the central nervous system and trigger inflammation.Looking ahead, there is the potential for the "liquid gold" medication to help treat symptoms of other neurological disorders, including amyotrophic lateral sclerosis (ALS), Alzheimer’s and Parkinson’s, according to Sergott — but the focus is on MS for now.While the latest study is small, Siegel said, it "looks promising in terms of modifying disease and improving thinking and vision, which can be affected in the early stages of MS." ... "Gold-containing analogies have long been treatments for rheumatoid arthritis — what is known as disease-modifying anti-rheumatic drugs," one doctor told Fox News Digital.An experimental medication called CNM-Au8 — a drinkable liquid with gold nanocrystals — has shown promising results in clinical trials in terms of improvements in MS symptoms.

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Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson’s : Newsroom - UT Southwestern, Dallas, Texas

Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and ... 13, 2024 – Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.However, studies have shown that in neurodegenerative conditions such as MS, PD, and amyotrophic lateral sclerosis (ALS) – also known as Lou Gehrig’s disease – this decline in the NAD+/NADH ratio is much faster and more severe.To determine whether CNM-Au8 was reaching its intended target in human patients, the UTSW researchers recruited 11 participants with relapsing MS and 13 with Parkinson’s for two phase two clinical trials, REPAIR-MS and REPAIR-PD.While these results are encouraging, additional studies are needed, Dr. Sguigna said. REPAIR-MS will continue to enroll participants to see whether similar findings can be reproduced in progressive MS.

The therapeutic effect of gold clusters in an EAE model of multiple sclerosis by regulating T cell differentiation - ScienceDirect

Upon entrying into the cells, gold clusters undergo degradation and oxidation, which is analyzed by synchrotron radiation x-ray absorption spectroscopy. Multiple sclerosis (MS) is caused by an aberrant autoimmune response in the central nervous system (CNS), which results in progressive ... Upon entrying into the cells, gold clusters undergo degradation and oxidation, which is analyzed by synchrotron radiation x-ray absorption spectroscopy. Multiple sclerosis (MS) is caused by an aberrant autoimmune response in the central nervous system (CNS), which results in progressive demyelination.Here, we firstly show that nano-sized gold clusters (GA, molecular formula Au29SG27) can significantly attenuate or reverse clinical symptoms and prevent neuronal demyelination in an experimental autoimmune encephalomyelitis (EAE) mouse model of MS when administered prophylactically or therapeutically.However, more serious side effects, such as infection, depression, subsequent autoimmune diseases, etc., and higher costs limit the wide use of these drugs and reduce the patient's compliance [4]. Meanwhile, some new treatments, such as cell-based therapies, are showing tantalizing promise in MS treatment [5], [6], [7]. However, there are still many technical problems in actual treatment, such as rejection of allograft, the large variability of the efficacy, the risk of inducing tumors and other side effects [8]. The development of new therapeutic drugs with low toxicity and high efficiency agIn this study, we set out to identify the therapeutic efficacy of gold clusters in animal models of MS, mouse MOG35–55-induced experimental autoimmune encephalomyelitis (EAE). We examined the effects of gold clusters on the morbidity, disease severity, inflammation and demyelination in the CNS of MOG peptide-immunized mice after prophylactic or therapeutic administration.

Marnie Goldberg - YouTube

This is the place for everyday fashion, wearable outfit ideas and easy makeup looks for the woman over 40, over 50, or anyone who likes a casual, realistic approach to style. I feature lots of Walmart and Amazon hauls, as well as a focus on more affordable brands with the occasional splurge ... This is the place for everyday fashion, wearable outfit ideas and easy makeup looks for the woman over 40, over 50, or anyone who likes a casual, realistic approach to style. I feature lots of Walmart and Amazon hauls, as well as a focus on more affordable brands with the occasional splurge from retailers like Nordstrom.

Ms. Gold | Resident Evil Wiki | Fandom

Ms. Gold was an Umbrella office worker who worked in The Hive. Gold was working at The Hive on the morning Spence sabotaged the facility, releasing the T-virus as an airborne pathogen. Soon after, the Red Queen computer system detected the virus in the atmosphere and began killing the employees, ... Ms. Gold was an Umbrella office worker who worked in The Hive. Gold was working at The Hive on the morning Spence sabotaged the facility, releasing the T-virus as an airborne pathogen. Soon after, the Red Queen computer system detected the virus in the atmosphere and began killing the employees, determining the outbreak to be now unstoppable.Soon after, the Red Queen computer system detected the virus in the atmosphere and began killing the employees, determining the outbreak to be now unstoppable. Gold was in an office when the doors locked, and died of asphyxia when Halon gas was pumped into the room.[1] Ms.

Gold nanocrystals linked to neuronal repair, remyelination in multiple sclerosis

SAN DIEGO — Data from an open-label extension of VISIONARY-MS support an association between gold nanocrystals and neuronal repair and remyelination in patients with stable multiple sclerosis and visual deficits, according to a presenter.CNM-Au8 is an oral suspension of gold nanocrystals ... SAN DIEGO — Data from an open-label extension of VISIONARY-MS support an association between gold nanocrystals and neuronal repair and remyelination in patients with stable multiple sclerosis and visual deficits, according to a presenter.CNM-Au8 is an oral suspension of gold nanocrystals that is being studied as an adjunct to disease-modifying therapy in MS.Previously, results of the randomized, double-blind, placebo-controlled VISIONARY-MS trial showed that CNM-Au8 improved visual function in patients with stable forms of MS who were on disease-modifying therapy and had a pre-existing visual deficit, Benjamin Greenberg, MD, professor and vice chair of clinical and translational research at UT Southwestern Medical Center, said during a late-breaking research presentation at the American Academy of Neurology Annual Meeting.Nearly all patients in the open-label extension of VISIONARY-MS showed MRI evidence of neuronal repair and remyelination.A presenter said CNM-Au8 achieved “a heretofore unseen clinical benefit” in MS.

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